Co-design of the smart sensors and integration into medical devices includes the appropriate integration of the different sensors containing microcontrollers, communication modules and adequate software applications for data processing in order to measure biomedical parameters (respiration rhythm, blood pressure, pulse, oxygen level, glycemia), other biomarkers that can be used for diagnosing or treat (e.g., sweat analysis using wearable microfluidic devices) different diseases, to assist patients in rehabilitation. The integration of wearable smart sensors into textile products is based on sensors' flexibility and miniaturization. Without flexibility or miniaturization, these sensors can be damaged by mechanical actions that may occur in textiles, considering that the textile is not a continuous surface but discrete.